av A Woldegiorgis · 2007 · Citerat av 6 — Propofol. Clozapin. Zolpidem. Sertralin. Oxazepam Citalopram. Blekinge. 6. <0.1 - 0.4. <0.8 - "Bioavailability and pharmacokinetics of oxazepam.". Eur. J. Clin.

Bensodiazepiner och Propofol avrådes till prematura barn, se nedan. Svensk förening Pharmacokinetics and Parmacodynamics of analgesic drugs. Third ed.

Like most anaesthetics, propofol is a γ-aminobutyric acid (GABA) receptor agonist. It has a favourable pharmacokinetic (PK) and pharmacodynamic (PD) profile, which has resulted in it becoming the most commonly used intravenous anaesthetic for the past three decades [ 2, 3, 4, 5, 6, 7 ]. Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model For the first time, a maternal-fetal PK model of propofol in pregnant ewes was successfully developed. This study narrows the gap in our knowledge in maternal-fetal PK model in human. We have compared the pharmacokinetics of propofol as an infusion in 10 control and 10 patients with cirrhosis. Anaesthesia was induced within 3-4 min during administration of an infusion of propofol 21 mg kg-1 h-1. After 5 min, the infusion was decreased in a stepwise manner to 12 mg kg-1 h-1 and subsequently 6 mg kg-1 h-1.

Propofol pharmacokinetics

It exerts its effects through potentiation of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) at the GABA_A receptor, and has gained widespread use due to its …. PROPOFOL (2,6-diisopropylphenol) is a water-insoluble intravenous anesthetic that is available as an oil-in-water lipid emulsion with 10% soybean oil (Diprivan®; AstraZeneca, London, United Kingdom). 1 Propofol lipid emulsion has been associated with a variety of drawbacks for which altered lipid emulsion or nonemulsion formulations have been developed. 2 Pharmacokinetics of propofol (Diprivan):5. Following IV bolus administration, propofol (Diprivan) CNS actions are terminated by redistribution from the brain to other compartments.

AU - Cortinez, L. I. AU - Anderson, B. J. Conclusions: Brain tumours might alter the pharmacokinetics of propofol. Caution should be exerted when using propofol. TCI in patients with frontal brain tumours 13 Mar 2008 Propofol pharmacokinetics in preterm and term neonates: the relevance of both postmenstrual and postnatal age.

Specimen: Hair or Fingernail ( Please select type of Specimen) Propofol Glucuronide Hair or Fingernail Drug Test Note: Fasting is not required for this test .

Oxazepam Citalopram. Blekinge. 6.

2020-01-17

Anesthesiology: The Journal of the American Society of Anesthesiologists.

Venous blood propofol concentrations were determined by h.p.l.c. with u.v. or fluorescence detection.
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with u.v.

The pharmacokinetics and protein binding of propofol were studied in ten patients with cirrhosis and in ten control patients undergoing elective surgery.
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Keywords propofol infusion pharmacokinetics Introduction Early pharmacokinetic studies of the intra-venous anaesthetic agent propofol, administered as a single i.v. bolus dose, have suggested that this agentwaseliminated veryrapidly fromthe body. Thiswasindicatedbyestimates ofelimi-nationhalf-life of1.5-5 handofsystemicclear-ance which exceeded

After 5 min, the infusion was decreased in a stepwise manner to 12 mg kg-1 h-1 and subsequently 6 mg kg-1 h-1. Se hela listan på journals.lww.com Se hela listan på academic.oup.com 2021-01-26 · Pharmacokinetics and Pharmacodynamics of Propofol designed to achieve a particular plasma concentration, they result in administration of a larger than necessary induc tion Propofol, the recently marketed intravenous induction agent for anaesthesia, is chemically unrelated to earlier anaesthetic drugs. This highly lipophilic agent has a fast onset and short, predictable duration of action due to its rapid penetration of the blood-brain barrier and distribution to the CNS, followed by redistribution to inactive tissue depots such as muscle and fat. intravenous infusion. Liver: cirrhosis. Pharmacokinetics: propofol.